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From: cj
, 122 months, post #1 |
Story that some of you might find interesting:
http://mobile.theverge.com/2014/4/10/5601420/lab-grown-vaginas-successfully-implanted-four-women
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From: cj
, 122 months, post #2 |
Ooops. Here's the normal
(non-mobile) link:
http://www.theverge.com/2014/4/10/5601420/lab-grown-vaginas-successfully-implanted-four-women
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From: guest
, 122 months, post #3 |
Wonder if lab grown penis will come next
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From: guest
, 122 months, post #4 |
the inability to get pregnant is probably a boon for some of the
people here...
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From: cj
, 122 months, post #5 |
Knowing that if I were to transition, I could get a "fully
functioning", real vagina is wonderful. Even if I didn't have the
rest of the child-bearing equipment (which I'm split on anyhow), I
wouldn't have some of the concerns (lubrication, dilation) that
other transwomen have.
Still have to deal with the other physical aspects that I don't
like... being "older", taller, bigger-built & masculine-looking
than other women (I'd make a very ugly woman)... and I still
wouldn't have the correct muscular-skeletal structure for a
woman... my movements and positioning wouldn't be as graceful or
natural as I'd like.
But it's another step in the right direction.
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From: guest (lily)
, 122 months, post #6 |
I heard Anthony Atala, the lead author of the Lancet Paper, on NPR
yesterday afternoon. He was asked about conception and giving
birth, He replied the 4 women described in the study had missing or
abnormal uteruses as a consequence of the same syndrome which
caused malformation of their vaginas, but that there was no reason
that a woman with an intact uterus and tissue engineered vagina of
this type could not conceive and deliver a child vaginally.
Whether transwomen could
benefit in a significant way from this technique used as part of
MTF GRS is unclear.
Somebody who actually knows something about the histology of
reproductive structures might be able to comment on whether there
is some source of the right kind of epithelium in the male. Maybe
the prostatic urethra or prostatic utricle?
As for lubrication, the current state of the art in GRS
vaginoplasty works pretty well for many transwomen. That is to say,
a neovagina produced by modern surgical procedures, particularly
where urethral tissue is exposed, isn't just pouch of dry skin.
There have been reports, going back decades, that the process of
invagination (inverting a flap of skin) can induce changes in the
skin used to line the neovagina so that it becomes
indistinguishable from "normal" vaginal epithelium. Most of these
studies have been on assigned-at-birth females with vaginal
agenisis or vaginal aplasia (like the 4 women with MRKHS on whom
Atala et. al. reported), but there have also been a few studies of
transwomen. It is not clear that it happens at all, or how often,
or what other factors might mitigate, if it does, but there are
reports of "normal" vaginal epithelium being detected in the
neovaginas of transwomen.
Perhaps more interesting is the of the supporting muscle and the
"biodegradable scaffold" implanted during the construction of the
vagina. Vaginal stenosis is a rare complication with modern GRS
surgery, but it is still a concern. As the population of older
transwomen increases, there are reports that some have (against the
advice of surgeons) stopped dilating for years without loss of
depth or elasticity -- but there are ethical concerns that would
prevent a controlled study the benefits of dilation. A muscular
vagina, that "grew into" and was anchored to the surrounding pelvic
tissue, would -- presumably -- be less of a worry.
It is another question altogether whether any surgeon would
attempt this technique on a transwoman. The cost-benefit would be
a tricky question. It might be a hard sell for who ever is writing
grant proposals for this research. These women were all quite young
(13 to 18) at the time of surgery. Saying that you are giving a
young woman with a congenital defect a chance at a "normal life"
sounds pretty good. Giving a transwoman a vagina that is wetter and
easier to maintain, not so much.
That said, one the women in the current study is reported to have
had a previous "failed" vaginoplasty with "intestinal tissue". I
know of a few transwomen who've had bad surgical outcomes who might
be very interested in volunteering for a follow-up study on the
implantation of a tissue engineered vagina on an
assigned-male-at-birth patient.
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From: cj
, 122 months, post #7 |
Thank you, lily, for your informative post. I'm still woefully
behind the times in keeping up with all the medical stuff. Every
little bit helps me to have hope that someday in my lifetime, it
might be possible for a man to become a woman capable of giving
birth naturally.
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From: Forestier
, 122 months, post #8 |
The problem is transwomen have no vaginal tissue to grow a vagina
from. They are genetic men.
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From: cj
, 122 months, post #9 |
From the article: "The vaginal organs themselves were generated using a combination
of cells � epithelial cells that line body cavities, as well as
muscle cells � biopsied from the women's genital areas."
Didn't specify that they had to be vaginal tissue.
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From: guest (Cleo Kraft)
, 122 months, post #10 |
Since the donor cells would probably have to come from a genetic
female then transplantation would probably be problematic (body
rejection). I think there is an old case of a M2F who had a vagina
transplant which resulted in complications due to rejection and
s/he died from it. Probably the same problems would have to be
dealt with. Then again people get heart transplants and survive so
/shrug. Would be nice if this would be the future of M2F surgery.
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From: guest (lily)
, 121 months, post #11 |
@Cleo Kraft, #10 Since the donor cells would probably have to come from a genetic
female then transplantation would probably be problematic (body
rejection)
cj has it right, the epithelial cells could come from some other
structure in the body of the patient.
Here is a report of a pilot study using epithelial cells cultured
from the mouth's of the patient to line the neovaginas of
transwomen.
http://www.ncbi.nlm.nih.gov/pubmed/24374675
.
I think there is an old case of a M2F who had a vagina transplant
which resulted in complications due to rejection and s/he died from
it.
You might thinking about Lili Elbe
who, it is widely reported, had ovaries transplanted into her
abdomen sometime around 1930, then had them removed when she
rejected the transplant.
There is some disagreement about this, though. Contemporary reports
also describe Elbe as a hermaphrodite, born with both testes and
ovaries.
She was "outed" as trans shortly before a fifth surgery -- an
attempt at vaginoplasty. She is reported to have died as a result
of complications to the surgery - not the rejection of the ovaries.
You probably didn't mean anything by it, but "s/he" is offensive
when describing a transwoman.
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